Concentrations of these receptors vary by location. They affect the concentrations of circulating catecholamines. The two major types of adrenergic receptors are alpha and beta. 9 This oxidative stress can affect many systems in the body, including the kidneys and brain. Xanthines are thought to play a role in ischemia-reperfusion injury and resistant hypertension. The major isoenzyme CYP1A2 is responsible for the demethylation of caffeine to dimethylxanthine. Paraxanthine also increases extracellular levels of dopamine.Ĭaffeine is rapidly absorbed in the gastrointestinal tract, and metabolized in the liver by the P450 system. The primary metabolite of caffeine is paraxanthine, in the methylxanthine class. Caffeine, through increasing levels of serotonin, can induce thermogenesis. Interestingly, amphetamines and cocaine also stimulate dopaminergic receptors. It also stimulates dopaminergic activity. Overview of energy drinks’ main ingredient with other stimulants effectsĬaffeine acts as an antagonist at adenosine receptors. 3 Other stimulant drugs in combination with energy drinks have been shown to cause fatal arrhythmias. ![]() In one study, college students who had stimulant prescriptions also reported using energy drinks, and drank alcohol (83% used energy drinks and 15% used energy drinks with alcohol). The highest incidence of energy drink consumption was among those individuals under 25 years old. 3Īdditionally, some studies have found that the frequency of energy drink use is directly correlated to an increased use of prescription stimulants, alcohol, nicotine, and illegal drugs. 14 Caffeine use has also been reported as a risk for other stimulant use. Caffeine blood/plasma serum toxicity ranges from 5–20 micrograms per milliliter. To put it into perspective, six ounces of coffee contains approximately 75 to 150 mg of caffeine. The recommended maximum daily dose of caffeine for an adult is 400mg. ![]() One can of energy drink contains 40–505 milligrams of caffeine (unknown content in the proprietary blend). This fact may compromise patient safety when ingesting more than the recommended amounts, or with other substances. There is not much information about the energy blend or potentially toxic effects from various combinations in the actual mixtures. Most energy drink studies have focused on the primary ingredient: caffeine. These blends may be problematic, for patients, providers, and researchers, as the PB is unknown. Other ingredients include an “energy blend” (interchangeable with proprietary blend). 2Ĭaffeine, sugar, and sodium are the only consistently listed contents in milligrams and grams. Among the top-selling energy drinks are Monster, Red Bull, Full Throttle, Sobe no fear, and Rockstar. This law means that some ingredients are kept secret. Manufacturers are not required to divulge all concentrations of ingredients under “proprietary blend” (PB) laws. Many other herbal extracts like ginseng and yohimbine.Today, energy drinks contain significantly more ingredients, such as: ![]() They originally contained caffeine, taurine, and carbohydrates. IntroductionĮnergy drinks became popular during the 1990’s. No conflicts of interest to report for this article. PubMed, Medline, PubChem, Neuroscience, and Behavioral Studies from 2010 to 2015. Keywords : A literature review was conducted using keywords energy drinks, proprietary blend, chemical compounds, athletic performance, addictive behavior, and policy. This article seeks to identify these risks and associations that have been linked to the consumption of energy drinks, and effective treatment. 6 Consumers are unaware of the dangerous side effects associated with these drinks in combination with other drugs, specifically, hyperthermia and arrhythmias. The estimated total sales in the United States was $5.4 billion (2006). 1 Yet these drinks are consumed by various age groups. Regulation by the Food and Drug Administration (FDA) is limited to dietary supplements, manufacturing, labeling, and marketing. Energy drinks: Safety, efficacy, and content | Įnergy drinks are one of the least studied over-the-counter supplements in abundant supply, interestingly, manufacturers determine their safety, efficacy, and content.
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